Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever

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dc.date.accessioned2018-09-14T11:15:08Z
dc.date.available2017-07-19T01:21:29Z
dc.date.available2010-01-10en_US
dc.date.available2010-01-10en_US
dc.date.available2010-01-10en_US
dc.date.available2010-01-10en_US
dc.date.available2010-01-10en_US
dc.date.available2010-01-10en_US
dc.date.available2010-01-10en_US
dc.date.available2010-01-10en_US
dc.date.available2018-09-14T11:15:08Z
dc.date.issued2010-03-01en_US
dc.description.abstractOBJECTIVES: To explore clinical and virological characteristics and describe the epidemiology of dengue in patients who presented with acute undifferentiated fever (AUF) at primary health centers (PHC) in Binh Thuan Province, Vietnam. METHODS: A prospective observational study was conducted from 2001 to 2006 to study the aetiology in AUF patients. Demographic and clinical information was obtained, and dengue polymerase chain reaction (RT-PCR) and serology were performed on a random selection of patients. RESULTS: Three hundred fifty-one serologically confirmed dengue patients including 68 primary and 283 secondary infections were included in this study. In 25% (86/351) dengue virus (DENV) was detected by RT-PCR among which 32 DENV-1, 16 DENV-2, 1 DENV-3 and 37 DENV-4 were identified. The predominant dengue serotype varied by year with seasonal fluctuation: DENV-4 in 2001-2002, DENV-1 and DENV-2 from 2003 to 2006. Primary dengue was more common in children. Higher viraemia levels (P=0.010) were found in primary infections compared to secondary infections. DENV-1 infected patients had higher viraemia levels than DENV-2 (P=0.003) and DENV-4 (P<0.001) infected patients. Clinical symptoms were often seen in adults. Few differences in clinical symptoms were found between primary and secondary infection and no significant differences in clinical symptoms between the serotypes were observed. CONCLUSIONS: Our data provide insight in the epidemiology, clinical profile and virological features of mild symptomatic dengue patients who presented to PHC with AUF in Vietnam.
dc.identifier.urihttp://localhost:8080/dspace7/handle/123456789/216
dc.languageEnglishen_US
dc.titleClinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated feveren_US
dc.typeJournal Article
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