Genetic epidemiology of dengue viruses in phae III trials of the CYD tetravalent dengue vaccine and implications for efficacy

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dc.date.accessioned2018-09-14T11:15:03Z
dc.date.available2017-10-11T01:12:07Z
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2017-08-03en_US
dc.date.available2018-09-14T11:15:03Z
dc.date.issued2017-09-05en_US
dc.description.abstractThis study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, including at epitope sites targeted by virus neutralising human monoclonal antibodies. Post-hoc analysis of all CYD14/15 trial participants revealed a statistically significant genotype-level VE association within DENV-4, where efficacy was lowest against genotype I. In subgroup analysis of trial participants age 9-16 years, VE estimates appeared more balanced within each serotype, suggesting that genotype-level heterogeneity may be limited in older children. Post-licensure surveillance is needed to monitor vaccine performance against the backdrop of DENV sequence diversity and evolution.
dc.identifier.urihttp://localhost:8080/dspace7/handle/123456789/180
dc.languageEnglishen_US
dc.titleGenetic epidemiology of dengue viruses in phae III trials of the CYD tetravalent dengue vaccine and implications for efficacyen_US
dc.typeJournal Article
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