Variation at HLA-DRB1 is associated with resistance to enteric fever

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dc.date.accessioned2018-09-14T11:15:04Z
dc.date.available2017-07-12T03:29:04Z
dc.date.available2014-10-15en_US
dc.date.available2014-10-15en_US
dc.date.available2014-10-15en_US
dc.date.available2014-10-15en_US
dc.date.available2014-10-15en_US
dc.date.available2014-10-15en_US
dc.date.available2014-10-15en_US
dc.date.available2014-10-15en_US
dc.date.available2018-09-14T11:15:04Z
dc.date.issued2014-12-01en_US
dc.description.abstractEnteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C(1). We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1. We replicated this association in 595 enteric fever cases and 386 controls from Nepal and also in a second independent collection of 151 cases and 668 controls from Vietnam. Imputation-based fine-mapping across the extended MHC region showed that the classical HLA-DRB1*04:05 allele (OR = 0.14, P = 2.60 × 10(-11)) could entirely explain the association at rs7765379, thus implicating HLA-DRB1 as a major contributor to resistance against enteric fever, presumably through antigen presentation.
dc.identifier.urihttp://localhost:8080/dspace7/handle/123456789/184
dc.languageEnglishen_US
dc.titleVariation at HLA-DRB1 is associated with resistance to enteric feveren_US
dc.typeJournal Article
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