Decrease of dysmenorrhoea with hormonal treatment is a marker of endometriosis severity.

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dc.contributor.authorMarcellin, Louis
dc.contributor.authorBourdon, Mathilde
dc.contributor.authorHoudre, Doriane
dc.contributor.authorMaignien, Chloe
dc.contributor.authorChardonnet, Antoine Gaudet
dc.contributor.authorBorghese, Bruno
dc.contributor.authorMantelet, Lorraine Maitrot
dc.contributor.authorSantulli, Pietro
dc.contributor.authorChapron, Charles
dc.date.accessioned2023-03-24T10:07:39Z
dc.date.available2023-03-24T10:07:39Z
dc.date.issued2023-01-12T00:00:00Z
dc.description.abstractIs a decrease in dysmenorrhoea after suppressive hormonal therapy a marker of the endometriosis phenotype and of greater disease severity?
dc.description.abstractRetrospective observational cohort study conducted in a French university hospital, between January 2004 and December 2019. Non-pregnant women aged younger than 42 years, who tested for dysmenorrhoea relief after suppressive hormonal therapy before surgery, and who had histological confirmation of endometriosis, were included. The comparisons were carried out according to the results of the suppressive hormonal test.
dc.description.abstractOf the 578 histologically proven endometriosis patients with preoperative pain symptoms, the rate of dysmenorrhoea decrease after suppressive hormonal therapy was 88.2% (n = 510). These patients had a higher incidence of deep infiltrating endometriosis (DIE) intestinal lesions (45.7% [233/510] versus 30.8% [21/68], P = 0.01) and an increased rate of multiple DIE lesions (two or more) (72.8% [287/394] versus 56.4% [22/39], P = 0.02). After multivariate analysis, decrease of dysmenorrhoea after suppressive hormonal therapy remained significantly associated with the severe DIE phenotype (adjusted OR 3.9, 95% CI 2.0 to 7.6, P < 0.001).
dc.description.abstractIn women with endometriosis, a decrease of dysmenorrhoea after suppressive hormonal therapy is associated with the DIE phenotype and is a marker of greater severity.
dc.identifier.doi10.1016/j.rbmo.2023.01.009
dc.identifier.issn1472-6491
dc.identifier.other36959070
dc.identifier.piiS1472-6483(23)00042-1
dc.identifier.pmid36959070
dc.identifier.urihttps://internal.dspace7-test.dspace-express.com/handle/123456789/1159
dc.language.isoen
dc.rightsCopyright © 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
dc.source.countryNetherlands
dc.source.journaltitleReproductive biomedicine online
dc.subjectcomplete surgery
dc.subjectdysmenorrhoea
dc.subjectendometriosis
dc.subjecthormonal treatment
dc.titleDecrease of dysmenorrhoea with hormonal treatment is a marker of endometriosis severity.
dc.typeJournal Article
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