X-Ray Study of Cembranoids with Flexible Rings from Boswellia papyrifera Resins Allowing Structural Revisions of Misleading Structures in the Past 70 Years.

Simple item page
dc.contributor.advisorTom Helen
dc.contributor.authorSura, Madhu Babu
dc.contributor.authorZhu, Yan-Xia
dc.contributor.authorCheng, Yongxian
dc.date.accessioned2023-03-23T07:40:29Z
dc.date.available2023-03-23T07:40:29Z
dc.date.issued2023-03-22T00:00:00Z
dc.description.abstract30 new highly oxygenated and stereogenic 14-membered macrocyclic diterpenoids, papyrifuranols A-Z (1-26) and AA-AD (27-30), and 8 known analogs were isolated from Boswellia papyrifera resins. All the structures were characterized by detailed spectral analyses, quantum calculations, X-ray diffraction, and modified Mosher's methods. Notably, six previously reported structures were revised. Our study points out misleading factors of macrocyclic cembranoids (CBs) representation in the past 7 decades by analysis of 25 X-ray structures, lending a hand for innately challengeable structure identification of such flexible macrocyclic CBs and avoiding following the tracks of an overturned cart during future structure characterization and total synthesis. Biosynthetic conversions of all the isolates were proposed and wound healing bioassays reveal that papyrifuranols N-P could significantly stimulate the proliferation and differentiation of umbilical cord mesenchymal stem cells.
dc.identifier.doi10.1002/chem.202300559
dc.identifier.issn1521-3765
dc.identifier.other36949022
dc.identifier.pmid36949022
dc.identifier.urihttps://internal.dspace7-test.dspace-express.com/handle/123456789/1157
dc.language.isoen
dc.rights© 2023 Wiley-VCH GmbH.
dc.source.beginpagee202300559
dc.source.countryGermany
dc.source.journaltitleChemistry (Weinheim an der Bergstrasse, Germany)
dc.subjectBoswellia papyrifera resins
dc.subjectSkeletal representations
dc.subjectStructural revisions
dc.subjectWound healing activity
dc.subjectcembranoids
dc.titleX-Ray Study of Cembranoids with Flexible Rings from Boswellia papyrifera Resins Allowing Structural Revisions of Misleading Structures in the Past 70 Years.
dc.typeJournal Article
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Volleybal Magazine (SAF IMPORT TEST)