Timing of CD8(+) T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengue
| dc.date.accessioned | 2018-09-14T11:14:56Z | |
| dc.date.available | 2017-07-12T05:11:31Z | |
| dc.date.available | 2018-09-14T11:14:56Z | |
| dc.date.issued | 2010-06-15 | en_US |
| dc.description.abstract | Immune activation is a feature of dengue hemorrhagic fever (DHF) and CD8+ T cell responses in particular have been suggested as having a role in the vasculopathy that characterizes this disease. By phenotyping CD8+ T cells (CD38+/HLA-DR+, CD38+/Ki-67+, or HLA-DR+/Ki-67+) in serial blood samples from children with dengue, we found no evidence of increased CD8+ T cell activation prior to the commencement of resolution of viremia or hemoconcentration. Investigations with MHC class I tetramers to detect NS3(133-142)-specific CD8+ T cells in two independent cohorts of children suggested the commencement of hemoconcentration and thrombocytopenia in DHF patients generally begins before the appearance of measurable frequencies of NS3(133-142)-specific CD8+ T cells. The temporal mismatch between the appearance of measurable surface activated or NS3(133-142)-specific CD8+ T cells suggests that these cells are sequestered at sites of infection, have phenotypes not detected by our approach, or that other mechanisms independent of CD8+ T cells are responsible for early triggering of capillary leakage in children with DHF. | |
| dc.identifier.uri | http://localhost:8080/dspace7/handle/123456789/121 | |
| dc.language | English | en_US |
| dc.title | Timing of CD8(+) T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengue | en_US |
| dc.type | Journal Article |