Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes
| dc.date.accessioned | 2018-09-14T11:15:00Z | |
| dc.date.available | 2017-07-12T03:45:45Z | |
| dc.date.available | 2018-09-14T11:15:00Z | |
| dc.date.issued | 2013-05-28 | en_US |
| dc.description.abstract | Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission. | |
| dc.identifier.uri | http://localhost:8080/dspace7/handle/123456789/150 | |
| dc.language | English | en_US |
| dc.title | Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes | en_US |
| dc.type | Journal Article |